Periodic pattern mining from spatio-temporal trajectory data

Rapid development in GPS tracking techniques produces a large number of spatio-temporal trajectory data. The analysis of these data provides us with a new opportunity to discover useful behavioural patterns. Spatio-temporal periodic pattern mining is employed to find temporal regularities for interesting places. Mining periodic patterns from spatio-temporal trajectories can reveal useful, important and valuable information about people's regular and recurrent movements and behaviours. Previous studies have been proposed to extract people's regular and repeating movement behavior from spatio-temporal trajectories. These previous approaches can target three following issues, (1) long individual trajectory; (2) spatial fuzziness; and (3) temporal fuzziness. First, periodic pattern mining is different to other pattern mining, such as association rule ming and sequential pattern mining, periodic pattern mining requires a very long trajectory from an individual so that the regular period can be extracted from this long single trajectory, for example, one month or one year period. Second, spatial fuzziness shows although a moving object can regularly move along the similar route, it is impossible for it to appear at the exactly same location. For instance, Bob goes to work everyday, and although he can follow a similar path from home to his workplace, the same location cannot be repeated across different days. Third, temporal fuzziness shows that periodicity is complicated including partial time span and multiple interleaving periods. In reality, the period is partial, it is highly impossible to occur through the whole movement of the object. Alternatively, the moving object has only a few periods, such as a daily period for work, or yearly period for holidays. However, it is insufficient to find effective periodic patterns considering these three issues only. This thesis aims to develop a new framework to extract more effective, understandable and meaningful periodic patterns by taking more features of spatio-temporal trajectories into account. The first feature is trajectory sequence, GPS trajectory data is temporally ordered sequences of geolocation which can be represented as consecutive trajectory segments, where each entry in each trajectory segment is closely related to the previous sampled point (trajectory node) and the latter one, rather than being isolated. Existing approaches disregard the important sequential nature of trajectory. Furthermore, they introduce both unwanted false positive reference spots and false negative reference spots. The second feature is spatial and temporal aspects. GPS trajectory data can be presented as triple data (x; y; t), x and y represent longitude and latitude respectively whilst t shows corresponding time in this location. Obviously, spatial and temporal aspects are two key factors. Existing methods do not consider these two aspects together in periodic pattern mining. Irregular time interval is the third feature of spatio-temporal trajectory. In reality, due to weather conditions, device malfunctions, or battery issues, the trajectory data are not always regularly sampled. Existing algorithms cannot deal with this issue but instead require a computationally expensive trajectory interpolation process, or it is assumed that trajectory is with regular time interval. The fourth feature is hierarchy of space. Hierarchy is an inherent property of spatial data that can be expressed in different levels, such as a country includes many states, a shopping mall is comprised of many shops. Hierarchy of space can find more hidden and valuable periodic patterns. Existing studies do not consider this inherent property of trajectory. Hidden background semantic information is the final feature. Aspatial semantic information is one of important features in spatio-temporal data, and it is embedded into the trajectory data. If the background semantic information is considered, more meaningful, understandable and useful periodic patterns can be extracted. However, existing methods do not consider the geographical information underlying trajectories. In addition, at times we are interested in finding periodic patterns among trajectory paths rather than trajectory nodes for different applications. This means periodic patterns should be identified and detected against trajectory paths rather than trajectory nodes for some applications. Existing approaches for periodic pattern mining focus on trajectories nodes rather than paths. To sum up, the aim of this thesis is to investigate solutions to these problems in periodic pattern mining in order to extract more meaningful, understandable periodic patterns. Each of three chapters addresses a different problem and then proposes adequate solutions to problems currently not addressed in existing studies. Finally, this thesis proposes a new framework to address all problems. First, we investigated a path-based solution which can target trajectory sequence and spatio-temporal aspects. We proposed an algorithm called Traclus (spatio-temporal) which can take spatial and temporal aspects into account at the same time instead of only considering spatial aspect. The result indicated our method produced more effective periodic patterns based on trajectory paths than existing node-based methods using two real-world trajectories. In order to consider hierarchy of space, we investigated existing hierarchical clustering approaches to obtain hierarchical reference spots (trajectory paths) for periodic pattern mining. HDBSCAN is an incremental version of DBSCAN which is able to handle clusters with different densities to generate a hierarchical clustering result using the single-linkage method, and then it automatically extracts clusters from a hierarchical tree. Thus, we modified traditional clustering method DBSCAN in Traclus (spatio-temporal) to HDBSCAN for extraction of hierarchical reference spots. The result is convincing, and reveals more periodic patterns than those of existing methods. Second, we introduced a stop/move method to annotate each spatio-temporal entry with a semantic label, such as restaurant, university and hospital. This method can enrich a trajectory with background semantic information so that we can easily infer people's repeating behaviors. In addition, existing methods use interpolation to make trajectory regular and then apply Fourier transform and autocorrelation to automatically detect period for each reference spot. An increasing number of trajectory nodes leads to an exponential increase of running time. Thus, we employed Lomb-Scargle periodogram to detect period for each reference spot based on raw trajectory without requiring any interpolation method. The results showed our method outperformed existing approaches on effectiveness and efficiency based on two real datasets. For hierarchical aspect, we extended previous work to find hierarchical semantic periodic patterns by applying HDBSCAN. The results were promising. Third, we apply our methodology to a case study, which reveals many interesting medical periodic patterns. These patterns can effectively explore human movement behaviors for positive medical outcomes. To sum up, this research proposed a new framework to gradually target the problems that existing methods cannot handle. These include: how to consider trajectory sequence, how to consider spatial temporal aspects together, how to deal with trajectory with irregular time interval, how to consider hierarchy of space and how to extract semantic information behind trajectory. After addressing all these problems, the experimental results demonstrate that our method can find more understandable, meaningful and effective periodic patterns than existing approaches

Characterization of Multi-Walled Carbon Nanotube Film Sensor and Ethanol Gas-Sensing Properties

Multi-wall carbon nanotubes (MWNTs) film-based sensor on the substrate of printed circuit board (PCB) with inter digital electrodes (IDE) were fabricated using layer-by-layer self-assembly, and the electrical properties of MWNTs film sensor were investigated through establishing models involved with number of self-assembled layers and IDE finger gap, and also its ethanol gas-sensing properties with varying gas concentration are characterized at room temperature. Through comparing with the thermal evaporation method, the experiment results shown that the layer-by-layer self-assembled MWNTs film sensor have a faster response and more sensitive resistance change when exposed to ethanol gas, indicated a prospective application for ethanol gas detection with high performance and low-cost

Structure-based substrate screening for an enzyme

<p>Abstract</p> <p>Background</p> <p>Nowadays, more and more novel enzymes can be easily found in the whole enzyme pool with the rapid development of genetic operation. However, experimental work for substrate screening of a new enzyme is laborious, time consuming and costly. On the other hand, many computational methods have been widely used in lead screening of drug design. Seeing that the ligand-target protein system in drug design and the substrate-enzyme system in enzyme applications share the similar molecular recognition mechanism, we aim to fulfill the goal of substrate screening by in silico means in the present study.</p> <p>Results</p> <p>A computer-aided substrate screening (CASS) system which was based on the enzyme structure was designed and employed successfully to help screen substrates of <it>Candida antarctica </it>lipase B (CALB). In this system, restricted molecular docking which was derived from the mechanism of the enzyme was applied to predict the energetically favorable poses of substrate-enzyme complexes. Thereafter, substrate conformation, distance between the oxygen atom of the alcohol part of the ester (in some compounds, this oxygen atom was replaced by nitrogen atom of the amine part of acid amine or sulfur atom of the thioester) and the hydrogen atom of imidazole of His224, distance between the carbon atom of the carbonyl group of the compound and the oxygen atom of hydroxyl group of Ser105 were used sequentially as the criteria to screen the binding poses. 223 out of 233 compounds were identified correctly for the enzyme by this screening system. Such high accuracy guaranteed the feasibility and reliability of the CASS system.</p> <p>Conclusion</p> <p>The idea of computer-aided substrate screening is a creative combination of computational skills and enzymology. Although the case studied in this paper is tentative, high accuracy of the CASS system sheds light on the field of computer-aided substrate screening.</p

Fault Diagnosis of Rotating Machinery Bearings Based on Improved DCNN and WOA-DELM

A bearing is a critical component in the transmission of rotating machinery. However, due to prolonged exposure to heavy loads and high-speed environments, rolling bearings are highly susceptible to faults, Hence, it is crucial to enhance bearing fault diagnosis to ensure safe and reliable operation of rotating machinery. In order to achieve this, a rotating machinery fault diagnosis method based on a deep convolutional neural network (DCNN) and Whale Optimization Algorithm (WOA) optimized Deep Extreme Learning Machine (DELM) is proposed in this paper. DCNN is a combination of the Efficient Channel Attention Net (ECA-Net) and Bi-directional Long Short-Term Memory (BiLSTM). In this method, firstly, a DCNN classification network is constructed. The ECA-Net and BiLSTM are brought into the deep convolutional neural network to extract critical features. Next, the WOA is used to optimize the weight of the initial input layer of DELM to build the WOA-DELM classifier model. Finally, the features extracted by the Improved DCNN (IDCNN) are sent to the WOA-DELM model for bearing fault diagnosis. The diagnostic capability of the proposed IDCNN-WOA-DELM method was evaluated through multiple-condition fault diagnosis experiments using the CWRU-bearing dataset with various settings, and comparative tests against other methods were conducted as well. The results indicate that the proposed method demonstrates good diagnostic performance

Comparisons of short-term and long-term results between laparoscopic between open pancreaticoduodenectomy for pancreatic tumors: A systematic review and meta-analysis

Objective: The efficacy of pancreaticoduodenectomy and open pancreaticoduodenectomy for pancreatic tumors is controversial. The study aims to compare the efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in the treatment of pancreatic tumors through systematic evaluation and meta-analysis.Methods: PubMed, Embase, Cochrane Library and Web of science databases were searched for clinical studies on the treatment of pancreatic tumors with LPD and OPD. The end time for the searches was 20 July 2022. Rigorous inclusion and exclusion criteria were used to screen the articles, the Cochrane manual was used to evaluate the quality of the included articles, and the stata15.0 software was used for statistical analysis of the indicators.Results: In total, 16 articles were included, including two randomized controlled trials and 14 retrospective studies. Involving a total of 4416 patients, 1275 patients were included in the LPD group and 3141 patients in the OPD group. The results of the meta-analysis showed that: the operation time of LPD was longer than that of OPD [WMD = 56.14,95% CI (38.39,73.89), p = 0.001]; the amount of intraoperative blood loss of LPD was less than that of OPD [WMD = −120.82,95% CI (−169.33, −72.30), p = 0.001]. No significant difference was observed between LPD and OPD regarding hospitalization time [WMD = −0.5,95% CI (−1.35, 0.35), p = 0.250]. No significant difference was observed regarding postoperative complications [RR = 0.96,95% CI (0.86,1.07, p = 0.463]. And there was no significant difference regarding 1-year OS and 3-year OS: 1-year OS [RR = 1.02,95% CI (0.97,1.08), p = 0.417], 3-year OS [RR = 1.10 95% CI (0.75, 1.62), p = 0.614%].Conclusion: In comparison with OPD, LPD leads to less blood loss but longer operation time, therefore the bleeding rate per unit time of LPD is less than that of OPD. LPD has obvious advantages. With the increase of clinical application of LPD, the usage of LPD in patients with pancreatic cancer has very good prospect. Due to the limitations of this paper, in future studies, more attention should be paid to high-quality, multi-center, randomized controlled studies

A Design for a Lithium-Ion Battery Pack Monitoring System Based on NB-IoT-ZigBee

With environmental issues arising from the excessive use of fossil fuels, clean energy has gained widespread attention, particularly the application of lithium-ion batteries. Lithium-ion batteries are integrated into various industrial products, which necessitates higher safety requirements. Narrowband Internet of Things (NB-IoT) is an LPWA (Low Power Wide Area Network) technology that provides IoT devices with low-power, low-cost, long-endurance, and wide-coverage wireless connectivity. This study addresses the shortcomings of existing lithium-ion battery pack detection systems and proposes a lithium-ion battery monitoring system based on NB-IoT-ZigBee technology. The system operates in a master-slave mode, with the subordinate module collecting and fusing multi-source sensor data, while the master control module uploads the data to local monitoring centers and cloud platforms via TCP and NB-IoT. Experimental validation demonstrates that the design functions effectively, accomplishing the monitoring and protection of lithium-ion battery packs in energy storage power stations

Poboljšanje enzimske proizvodnje cefaleksina upotrebom velikih koncentracija supstrata i uklanjanjem produkata reakcije kompleksiranjem in situ

Cephalexin (CEX) was synthesized with 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) and D(–)-phenylglycine methyl ester (PGME) using immobilized penicillin G acylase from Escherichia coli. It was found that substrate concentration and in situ product could remarkably influence the ratio of synthesis to hydrolysis (S/H) and the efficiency of CEX synthesis. The optimal ratio of enzyme to substrate was 65 IU/mM 7-ADCA. High substrate concentration improved the 7-ADCA conversion from 61 to 81 % in the process without in situ product removal (ISPR), while in the synthetic process with ISPR, high substrate concentration increased the 7-ADCA conversion from 88 to 98 %. CEX was easily separated from CEX/β-naphthol complex and its purity and overall yield were 99 and 70 %, respectively.Primjenom imobilizirane Penicilin-G-acilaze iz bakterije Escherichia coli sintetiziran je cefaleksin (CEX) iz 7-amino-3-deacetoksicefalosporanske kiseline (7-ADCA) i D(-)-fenilglicin-metilnog estera (PGME). Koncentracije supstrata i produkta in situ mogu znatno utjecati na omjer sinteze i hidrolize (S/H) i djelotvornost sinteze cefaleksina. Optimalni omjer enzima i supstrata iznosio je 65 IU/mM 7-ADCA. Velika koncentracija supstrata poboljšala je konverziju 7-ADCA sa 61 na 81 % u procesu bez uklanjanja produkta in situ (ISPR), a s 88 na 98 % u procesu sa ISPR. Cefaleksin je lako uklonjen iz kompleksa CEX/β-naftol, a dobiveni je proizvod imao čistoću od 99 % i ukupni prinos od 70 %